Rehabilitating Cough Dysfunction in Parkinson's Disease: A Randomized Controlled Trial

TitleRehabilitating Cough Dysfunction in Parkinson's Disease: A Randomized Controlled Trial
Publication TypeJournal Article
Year of Publication2022
AuthorsTroche MS, Curtis JA, Sevitz JS, Dakin AE, Perry SE, Borders JC, Grande AA, Mou Y, Vanegas-Arroyave N, Hegland KW
JournalMovement Disorders
Volume38
Issue2
Date Published11/2022
Abstract

Background

Disorders of airway protection (cough and swallowing) are pervasive in Parkinson's disease (PD) resulting in a high incidence of aspiration pneumonia and death. However, there are no randomized controlled trials comparing strength and skill-based approaches to improve airway protection in PD.

Objectives

The aim of this study was to compare expiratory muscle strength training (EMST) and sensorimotor training for airway protection (smTAP) to improve cough-related outcomes in people with PD.

Methods

Participants with PD and dysphagia were recruited for this prospective phase II randomized-blinded controlled clinical trial. Participants completed baseline assessment, 5 weeks of EMST or smTAP, and a post-training assessment. Primary outcome measures included maximum expiratory pressure (MEP) and voluntary cough peak expiratory flow rate (PEFR). Mixed effects models were used to assess the effects of EMST and smTAP on outcomes.

Results

A total of 65 participants received either EMST (n = 34) or smTAP (n = 31). MEP improved from pre- to post-treatment for smTAP (P < 0.001, d = 0.19) and EMST (P < 0.001, d = 0.53). Voluntary PEFR increased from pre- to post-treatment for smTAP (P < 0.001, d = 0.19) and EMST (P < 0.001, d = 0.06). Moreover, reflex cough PEFR (P < 0.001, d = 0.64), reflex cough expired volume (P < 0.001, d = 0.74), and urge to cough (P = 0.018, OR = 2.70) improved for the smTAP group but not for the EMST group.

Conclusions

This clinical trial confirmed the efficacy of smTAP to improve reflex and voluntary cough function, above and beyond EMST, the current gold standard. © 2022 International Parkinson and Movement Disorder Society.

URLhttps://movementdisorders.onlinelibrary.wiley.com/doi/abs/10.1002/mds.29268?casa_token=CfawbyEl_-wAAAAA%3AJCUPfnhYB3suAXeLqOoC4WHrX5s0H6JSAnF-MeVLkVplkpQgiMaibbYy__OBYDn5mzVuYl-GCEo6IjE
DOI10.1002/mds.29268